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(1) MIT: New insights on fusion power

David Chandler, MIT News Office
December 3, 2008

Research carried out at MIT's Alcator C-Mod fusion reactor may have brought the promise of fusion as a future power source a bit closer to reality, though scientists caution that a practical fusion powerplant is still decades away.

Adapted from - http://web.mit.edu/newsoffice/2008/fusion-results-tt1203.html


(2)Disappearing superconductivity reappears -- in 2-D

Scientists studying a material that appeared to lose its ability to carry current with no resistance say new measurements reveal that the material is indeed a superconductor -- but only in two dimensions. Equally surprising, this new form of 2-D superconductivity emerges at a higher temperature than ordinary 3-D superconductivity in other compositions of the same material.

Adapted from - http://www.bnl.gov/bnlweb/pubaf/pr/PR_display.asp?prID=865

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December 3, 2008

ChemBank


ChemBank - Database

Chemistry Online Resources

Link - http://chembank.broad.harvard.edu/

"ChemBank is a public, web-based informatics environment created by the Broad Institute's Chemical Biology Program and funded in large part by the National Cancer Institute's Initiative for Chemical Genetics (ICG). This knowledge environment includes freely available data derived from small molecules and small-molecule screens, and resources for studying the data so that biological and medical insights can be gained. ChemBank is intended to guide chemists synthesizing novel compounds or libraries, to assist biologists searching for small molecules that perturb specific biological pathways, and to catalyze the process by which drug hunters discover new and effective medicines.

ChemBank stores an increasingly varied set of cell measurements derived from, among other biological objects, cell lines treated with small molecules. Analysis tools are available and are being developed that allow the relationships between cell states, cell measurements and small molecules to be determined. Currently, ChemBank stores information on hundreds of thousands of small molecules and hundreds of biomedically relevant assays that have been performed at the ICG in collaborations involving biomedical researchers worldwide. These scientists have agreed to perform their experiments in an open data-sharing environment.

The goals of ChemBank are to provide life scientists unfettered access to biomedically relevant data and tools heretofore available almost exclusively in the private sector. We intend for ChemBank to be a planning and discovery tool for chemists, biologists, and drug hunters anywhere, with the only necessities being a computer, access to the Internet, and a desire to extract knowledge from public experiments whose greatest value is likely to reside in their collective sum"[1].
1.http://chembank.broad.harvard.edu/

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DrugBank


DrugBank - Database

Chemistry Online Resources

Link - http://www.drugbank.ca/index.html

"The DrugBank database is a unique bioinformatics and cheminformatics resource that combines detailed drug (i.e. chemical, pharmacological and pharmaceutical) data with comprehensive drug target (i.e. sequence, structure, and pathway) information. The database contains nearly 4800 drug entries including >1,350 FDA-approved small molecule drugs, 123 FDA-approved biotech (protein/peptide) drugs, 71 nutraceuticals and >3,243 experimental drugs. Additionally, more than 2,500 non-redundant protein (i.e. drug target) sequences are linked to these FDA approved drug entries. Each DrugCard entry contains more than 100 data fields with half of the information being devoted to drug/chemical data and the other half devoted to drug target or protein data"[1].
1.http://www.drugbank.ca/index.html

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Chemical Structure Lookup Service 2008

Chemical Structure Lookup Service 2008

Chemistry Online Resources

Link - http://cholla.chemnavigator.com/cgi-bin/lookup/search

Release 09/2008: search in 57 million indexed structures from over 100 databases (40 million unique structures)

Analytical Inorganic Organic Physical

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Compendium of Pesticide Common Names

Compendium of Pesticide Common Names

Chemistry Online Resources

Link - http://www.alanwood.net/pesticides/

"For purposes of trade, registration and legislation, and for use in popular and scientific publications, pesticides need names that are short, distinctive, non-proprietary and widely-accepted. Systematic chemical names are rarely short and are not convenient for general use, and so standards bodies assign common names to the active ingredients of pesticides. More than 1100 of these official pesticide names have been assigned by the International Organization for Standardization (ISO), in accordance with an established system of nomenclature.

This Compendium is believed to be the only place where all of the ISO-approved standard names of chemical pesticides are listed. It also includes approved names from national and international bodies for pesticides that do not have ISO names"[1].
1.http://www.alanwood.net/pesticides/

Analytical Inorganic Organic Physical

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ChemExper Chemical Directory


ChemExper Chemical Directory
Chemistry Online Resources

Link - http://www.chemexper.com/

"The ChemExper Chemical Directory displays information about chemicals (physical and chemical characteristics, structure, MSDS and more.) on the Internet in order to create a world-wide database. It is free to consult and easily accessible over the Internet on any computer using a web browser.
The ChemExper Chemical Directory contains for now over 200,000 different chemicals, 10,000 MSDS and over 10,000 IR spectra. The directory can be searched by registry number, molecular formula, chemical name or synonyms in different languages as well as by physical and chemical characteristics and combinations of those data. The ChemExper Chemical Directory may also be searched by substructure"[1].
1.http://www.chemexper.com/


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BioCyc Open Chemical Database


BioCyc Open Chemical Database

Chemistry Online Resources

Link - http://biocyc.org/open-compounds.shtml

"The BioCyc Open Chemical Database (BOCD) is a collection of chemical compound data from the BioCyc databases. Most of the compounds act as substrates in enzyme-catalyzed metabolic reactions, but some compounds serve as enzyme activators, inhibitors, or cofactors. Chemical structures are provided for the majority of compounds. The compounds include extensive lists of synonyms, and have undergone several types of quality control, including validation by a reaction-balance checker applied to the BioCyc databases.

Unlike other DBs in the BioCyc collection, BOCD is not a full Pathway/Genome Database. It contains only chemical compounds. It is also not species specific"[1].
1.http://biocyc.org/open-compounds.shtml

Analytical Inorganic Organic Physical

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NIST Chemistry WebBook


NIST Chemistry WebBook

Chemistry online Resources

Link - http://webbook.nist.gov/chemistry/

"This site provides thermochemical, thermophysical, and ion energetics data compiled by NIST under the Standard Reference Data Program.

The National Institute of Standards and Technology (NIST) uses its best efforts to deliver a high quality copy of the Database and to verify that the data contained therein have been selected on the basis of sound scientific judgment. However, NIST makes no warranties to that effect, and NIST shall not be liable for any damage that may result from errors or omissions in the Database.

The NIST Chemistry WebBook was developed in part with funds from the Systems Integration for Manufacturing Applications (SIMA) program at NIST"[1].
1.http://webbook.nist.gov/chemistry/


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eMolecules


eMolecules - Chem Google

Chemistry online Resources

Link - http://www.emolecules.com/

Find Suppliers and Information for over 10 Million Unique Chemicals!.

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ZINC - Database


ZINC - Database

Chemistry online Resources

Link - http://zinc.docking.org/

Welcome to ZINC, a free database of commercially-available compounds for virtual screening. ZINC contains over 8 million purchasable compounds in ready-to-dock, 3D formats. ZINC is provided by the Shoichet Laboratory in the Department of Pharmaceutical Chemistry at the University of California, San Francisco (UCSF). To cite ZINC, please reference: Irwin and Shoichet, J. Chem. Inf. Model. 2005;45(1):177-82 PDF, DOI. We thank NIGMS for financial support (GM71896).


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PubChem


PubChem - Database

Chemistry online Resources

Link - http://pubchem.ncbi.nlm.nih.gov/

PubChem provides information on the biological activities of small molecules. It is a component of NIH's Molecular Libraries Roadmap Initiative. If you would like to learn more about how to use the PubChem resources, please go to our help page.

PubChem Compound: Search unique chemical structures using names, synonyms or keywords. Links to available biological property information are provided for each compound.

PubChem Substance: Search deposited chemical substance records using names, synonyms or keywords. Links to biological property information and depositor web sites are provided.

PubChem BioAssay: Search bioassay records using terms from the bioassay description, for example "cancer cell line". Links to active compounds and bioassay results are provided.

Structure Search: Search PubChem's Compound database using a chemical structure as the query. Structures may be sketched or specified by SMILES, MOL files, or other formats.


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Free Chemistry Hand Books

Hand Books

This site provides thermochemical, thermophysical, and ion energetics data compiled by NIST under the Standard Reference Data Program.


Learn Chemistry Online - Free online courses